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Contraindicated (one)pentobarbital will decrease the extent or result of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with robust CYP3A4 inducers is just not suggestedpentobarbital will lessen the level or influence of amiodarone by affecting hepatic/intestinal enzyme CYP3A4 metabol